Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers

Constitutive phosphatidylinositol 3-kinase (PI3K)-AKT activation has a causal role in adult T-cell leukaemia-lymphoma (ATLL) and other cancers. ATLL cells do not harbour genetic alterations in PTEN and PI3KCA but express high levels of PTEN that is highly phosphorylated at its C-terminal tail. Here...

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Main Authors: Nakahata, Shingo, Ichikawa, Tomonaga, Maneesaay, Phudit, Saito, Yusuke, Nagai, Kentaro, Tamura, Tomohiro, Manachai, Nawin, Yamakawa, Norio, Hamasaki, Makoto, Kitabayashi, Issay, Arai, Yasuhito, Kanai, Yae, Taki, Tomohiko, Abe, Takaya, Kiyonari, Hiroshi, Shimoda, Kazuya, Ohshima, Koichi, Horii, Akira, Shima, Hiroshi, Taniwaki, Masafumi, Yamaguchi, Ryoji, Morishita, Kazuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948061/
https://ncbi.nlm.nih.gov/pubmed/24569712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4393
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