Diethylstilbestrol (DES)-Stimulated Hormonal Toxicity is Mediated by ERα Alteration of Target Gene Methylation Patterns and Epigenetic Modifiers (DNMT3A, MBD2, and HDAC2) in the Mouse Seminal Vesicle

Background: Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin...

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Autors principals: Li, Yin, Hamilton, Katherine J., Lai, Anne Y., Burns, Katherine A., Li, Leping, Wade, Paul A., Korach, Kenneth S.
Format: Artigo
Idioma:Inglês
Publicat: National Institute of Environmental Health Sciences 2013
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Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948038/
https://ncbi.nlm.nih.gov/pubmed/24316720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1307351
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