Targeting Gli Transcription Activation by Small Molecule Suppresses Tumor Growth

Targeted inhibition of Hedgehog signaling at the cell membrane has been associated with anti-cancer activity in preclinical and early clinical studies. Hedgehog signaling involves activation of Gli transcription factors that can also be induced by alternative pathways. In this study we identified an...

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Hauptverfasser: Bosco-Clément, Geneviève, Zhang, Fang, Chen, Zhao, Zhou, Hai-Meng, Li, Hui, Mikami, Iwao, Hirata, Tomomi, Yagui-Beltran, Adam, Lui, Natalie, Do, Hanh T., Cheng, Tiffany, Tseng, Hsin-Hui, Choi, Helen, Fang, Li-Tai, Kim, Il-Jin, Yue, Dongsheng, Wang, Changli, Zheng, Qingfeng, Fujii, Naoaki, Mann, Michael, Jablons, David M., He, Biao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947751/
https://ncbi.nlm.nih.gov/pubmed/23686308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.164
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