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Mechanisms of Glucagon Degradation at Alkaline pH

Glucagon is unstable and undergoes degradation and aggregation in aqueous solution. For this reason, its use in portable pumps for closed loop management of diabetes is limited to very short periods. In this study, we sought to identify the degradation mechanisms and the bioactivity of specific degr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Caputo, Nicholas, Castle, Jessica R., Bergstrom, Colin P., Carroll, Julie M., Bakhtiani, Parkash A., Jackson, Melanie A., Roberts, Charles T., David, Larry L., Ward, W. Kenneth
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947653/
https://ncbi.nlm.nih.gov/pubmed/23651991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2013.04.005
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