Mechanisms of Glucagon Degradation at Alkaline pH

Glucagon is unstable and undergoes degradation and aggregation in aqueous solution. For this reason, its use in portable pumps for closed loop management of diabetes is limited to very short periods. In this study, we sought to identify the degradation mechanisms and the bioactivity of specific degr...

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Bibliographic Details
Main Authors:	Caputo, Nicholas, Castle, Jessica R., Bergstrom, Colin P., Carroll, Julie M., Bakhtiani, Parkash A., Jackson, Melanie A., Roberts, Charles T., David, Larry L., Ward, W. Kenneth
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3947653/ https://ncbi.nlm.nih.gov/pubmed/23651991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2013.04.005
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Mechanisms of Glucagon Degradation at Alkaline pH

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