Mechanisms of Glucagon Degradation at Alkaline pH

Glucagon is unstable and undergoes degradation and aggregation in aqueous solution. For this reason, its use in portable pumps for closed loop management of diabetes is limited to very short periods. In this study, we sought to identify the degradation mechanisms and the bioactivity of specific degr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Caputo, Nicholas, Castle, Jessica R., Bergstrom, Colin P., Carroll, Julie M., Bakhtiani, Parkash A., Jackson, Melanie A., Roberts, Charles T., David, Larry L., Ward, W. Kenneth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947653/
https://ncbi.nlm.nih.gov/pubmed/23651991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2013.04.005
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