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Interleukin-1β enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75(NTR) and sortillin

Many types of injury such as seizure, ischemia, and oxidative stress cause upregulation of the p75 neurotrophin receptor (p75(NTR)) in brain neurons, where it promotes apoptosis, however the mechanism by which p75(NTR) is regulated under these conditions is not well understood. Proinflammatory cytok...

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Autors principals: Choi, Soyoung, Friedman, Wilma J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947643/
https://ncbi.nlm.nih.gov/pubmed/24211304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2013.10.058
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