Inhibition of c-Src Blocks Estrogen-induced Apoptosis and Restores Estrogen-Stimulated Growth in Long-term Estrogen-Deprived Breast Cancer Cells

PURPOSE: Our publications demonstrate that physiological concentrations of estrogen (E(2)) induce endoplasmic reticulum and oxidative stress which finally result in apoptosis in E(2)-deprived breast cancer cells, MCF-7:5C. c-Src is involved in the process of E(2)-induced stress. To mimic the clinica...

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Main Authors: Fan, Ping, Agboke, Fadeke A., McDaniel, Russell E., Sweeney, Elizabeth E., Zou, Xiaojun, Creswell, Karen, Jordan, V. Craig
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947251/
https://ncbi.nlm.nih.gov/pubmed/24183378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2013.10.001
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