Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects

Aseptic implant loosening related to implant wear particle-induced inflammation is the most common cause of failure after joint replacement. Modulation of the inflammatory reaction to the wear products represents a rational approach for preventing aseptic implant failure. Long-term treatment using a...

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Bibliografiske detaljer
Main Authors: Ren, Ke, Dusad, Anand, Yuan, Fang, Yuan, Hongjiang, Purdue, P. Edward, Fehringer, Edward V., Garvin, Kevin L., Goldring, Steven R., Wang, Dong
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946775/
https://ncbi.nlm.nih.gov/pubmed/24326124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.11.024
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