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The Hippo Pathway is Activated and is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy
RATIONALE: Mutations in the intercalated disc (ID) proteins, such as plakophilin 2 (PKP2) cause arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac myocytes by fibro-adipocytes, cardiac dysfunction, arrhythmias and sudden death. OBJECTIVE: To delineate the molecular...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3946717/ https://ncbi.nlm.nih.gov/pubmed/24276085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.302810 |
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