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Knock Down of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro
RATIONALE: PKP2, encoding plakophilin 2 (PKP2), is the most common causal gene for arrhythmogenic cardiomyopathy (AC). OBJECTIVE: To characterize miRNAs expression profile in PKP2-deficient cells METHODS AND RESULTS: Control and PKP2-knock down HL-1 (HL-1(Pkp2-shRNA)) cells were screened for 750 miR...
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| Publicado no: | Circ Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5010490/ https://ncbi.nlm.nih.gov/pubmed/27470638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308422 |
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