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The Hippo Pathway is Activated and is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

RATIONALE: Mutations in the intercalated disc (ID) proteins, such as plakophilin 2 (PKP2) cause arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac myocytes by fibro-adipocytes, cardiac dysfunction, arrhythmias and sudden death. OBJECTIVE: To delineate the molecular...

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Hlavní autoři: Chen, Suet Nee, Gurha, Priyatansh, Lombardi, Raffaella, Ruggiero, Alessandra, Willerson, James T., Marian, AJ
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946717/
https://ncbi.nlm.nih.gov/pubmed/24276085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.302810
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