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DNA-Catalyzed Hydrolysis of Esters and Aromatic Amides

We previously reported that DNA catalysts (deoxyribozymes) can hydrolyze DNA phosphodiester linkages, but DNA-catalyzed amide bond hydrolysis has been elusive. Here we used in vitro selection to identify DNA catalysts that hydrolyze ester linkages as well as DNA catalysts that hydrolyze aromatic ami...

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Detalhes bibliográficos
Main Authors: Brandsen, Benjamin M., Hesser, Anthony R., Castner, Marissa A., Chandra, Madhavaiah, Silverman, Scott K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946404/
https://ncbi.nlm.nih.gov/pubmed/24127695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4077233
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