Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production

Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin (Ig) heavy-chain (hIGH), kappa-chain (hIGK), an...

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Detalhes bibliográficos
Main Authors: Matsushita, Hiroaki, Sano, Akiko, Wu, Hua, Jiao, Jin-an, Kasinathan, Poothappillai, Sullivan, Eddie J., Wang, Zhongde, Kuroiwa, Yoshimi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946162/
https://ncbi.nlm.nih.gov/pubmed/24603704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090383
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