Triple Immunoglobulin Gene Knockout Transchromosomic Cattle: Bovine Lambda Cluster Deletion and Its Effect on Fully Human Polyclonal Antibody Production

Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin (Ig) heavy-chain (hIGH), kappa-chain (hIGK), an...

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Main Authors: Matsushita, Hiroaki, Sano, Akiko, Wu, Hua, Jiao, Jin-an, Kasinathan, Poothappillai, Sullivan, Eddie J., Wang, Zhongde, Kuroiwa, Yoshimi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946162/
https://ncbi.nlm.nih.gov/pubmed/24603704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090383
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