Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage

Asparaginyl endopeptidase (AEP) is an endo/lysosomal cysteine endopeptidase with a preference for an asparagine residue at the P1 site and plays an important role in the maturation of toll-like receptors 3/7/9. AEP is known to undergo autoproteolytic maturation at acidic pH for catalytic activation....

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Detalhes bibliográficos
Main Authors: Zhao, Lixia, Hua, Tian, Crowley, Christopher, Ru, Heng, Ni, Xiangmin, Shaw, Neil, Jiao, Lianying, Ding, Wei, Qu, Lu, Hung, Li-Wei, Huang, Wei, Liu, Lei, Ye, Keqiang, Ouyang, Songying, Cheng, Genhong, Liu, Zhi-Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945893/
https://ncbi.nlm.nih.gov/pubmed/24407422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.4
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