Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

Asparaginyl endopeptidase (AEP or legumain) is a lysosomal cysteine protease that cleaves protein substrates on the C-terminal side of asparagine. AEP plays a pivotal role in the endosome/lysosomal degradation system and is implicated in antigen processing. The processing of the lysosomal proteases...

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Detalles Bibliográficos
Main Authors: Chan, Chi-Bun, Abe, Michiyo, Hashimoto, Noriyoshi, Hao, Chunhai, Williams, Ifor R., Liu, Xia, Nakao, Shinji, Yamamoto, Akitsugu, Zheng, Chengyun, Henter, Jan-Inge, Meeths, Marie, Nordenskjold, Magnus, Li, Shi-Yong, Hara-Nishimura, Ikuko, Asano, Masahide, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626726/
https://ncbi.nlm.nih.gov/pubmed/19106291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809824105
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