Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS

OBJECTIVE: Our objective was to determine whether altered naive CD4 T-cell biology contributes to development of disease progression in secondary progressive multiple sclerosis (SPMS). METHODS: We compared the naive CD4 T-cell gene expression profiles of 19 patients with SPMS and 14 healthy controls...

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Hlavní autoři: Zastepa, Evelyn, Fitz-Gerald, Leslie, Hallett, Michael, Antel, Jack, Bar-Or, Amit, Baranzini, Sergio, Lapierre, Yves, Haegert, David G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945666/
https://ncbi.nlm.nih.gov/pubmed/24453076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000000146
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