Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

Protein aggregation into intracellular inclusions is a key feature of many neurodegenerative disorders. A common theme has emerged that inappropriate self-aggregation of misfolded or mutant polypeptide sequences is detrimental to cell health. Yet protein quality control mechanisms may also deliberat...

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Главные авторы: Polling, Saskia, Mok, Yee-Foong, Ramdzan, Yasmin M., Turner, Bradley J., Yerbury, Justin J., Hill, Andrew F., Hatters, Danny M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945328/
https://ncbi.nlm.nih.gov/pubmed/24425868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520189
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