Antisense Oligonucleotide Against GSK-3β in Brain of SAMP8 Mice Improves Learning and Memory and Decreases Oxidative Stress: Involvement of Transcription Factor Nrf2 and Implications for Alzheimer Disease

Glycogen synthase kinase (GSK) -3β is a multifunctional protein that has been implicated in the pathological characteristics of Alzheimer’s disease (AD), including the heightened levels of neurofibrillary tangles, amyloid-beta (Aβ) and neurodegeneration. In this study we used 12 month old SAMP8 mice...

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Main Authors: Farr, Susan A., Ripley, Jessica L., Sultana, Rukhsana, Zhang, Zhaoshu, Niehoff, Michael L., Platt, Thomas L., Murphy, M. Paul, Morley, John E., Kumar, Vijaya, Butterfield, D. Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945161/
https://ncbi.nlm.nih.gov/pubmed/24355211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.11.014
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