Using Systems Approaches to Address Challenges for Clinical Implementation of Pharmacogenomics

Many genetic variants have been shown to affect drug response through changes in drug efficacy and likelihood of adverse effects. Much of pharmacogenomic science has focused on discovering and clinically implementing single gene variants with large effect sizes. Given the increasing complexities of...

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Bibliographic Details
Main Authors: Karnes, Jason H, Van Driest, Sara, Bowton, Erica A, Weeke, Peter E, Mosley, Jonathan D, Peterson, Josh F, Denny, Joshua C, Roden, Dan M
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944797/
https://ncbi.nlm.nih.gov/pubmed/24319008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/wsbm.1255
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