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Using Systems Approaches to Address Challenges for Clinical Implementation of Pharmacogenomics

Many genetic variants have been shown to affect drug response through changes in drug efficacy and likelihood of adverse effects. Much of pharmacogenomic science has focused on discovering and clinically implementing single gene variants with large effect sizes. Given the increasing complexities of...

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Detalhes bibliográficos
Main Authors: Karnes, Jason H, Van Driest, Sara, Bowton, Erica A, Weeke, Peter E, Mosley, Jonathan D, Peterson, Josh F, Denny, Joshua C, Roden, Dan M
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944797/
https://ncbi.nlm.nih.gov/pubmed/24319008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/wsbm.1255
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