Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer’s disease immunotherapy candidate bapineuzumab complexed with amyloid-β

Bapineuzumab (AAB-001) and its derivative (AAB-003) are humanized versions of the anti-Aβ murine antibody 3D6 and are immunotherapy candidates in Alzheimer’s disease. The common Fab fragment of these immunotherapies has been expressed, purified and crystallized in complex with β-amyloid peptides (re...

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Bibliographic Details
Main Authors: Crespi, Gabriela A. N., Ascher, David B., Parker, Michael W., Miles, Luke A.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2014
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944706/
https://ncbi.nlm.nih.gov/pubmed/24598931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14001642
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