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Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer’s disease immunotherapy candidate bapineuzumab complexed with amyloid-β
Bapineuzumab (AAB-001) and its derivative (AAB-003) are humanized versions of the anti-Aβ murine antibody 3D6 and are immunotherapy candidates in Alzheimer’s disease. The common Fab fragment of these immunotherapies has been expressed, purified and crystallized in complex with β-amyloid peptides (re...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
International Union of Crystallography
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3944706/ https://ncbi.nlm.nih.gov/pubmed/24598931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14001642 |
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