Pharmacological activation of NQO1 increases NAD(+) levels and attenuates cisplatin-mediated acute kidney injury in mice

Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors. In addition to its antitumor activity, cisplatin affects normal cells and may induce adverse effects, such as ototoxicity, nephrotoxicity, and neuropathy. Various mechanisms, such as DNA adduct formation, mitochon...

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מידע ביבליוגרפי
Main Authors: Oh, Gi-Su, Kim, Hyung-Jin, Choi, Jae-Hyuck, Shen, AiHua, Choe, Seong-Kyu, Karna, Anzani, Lee, Seung Hoon, Jo, Hyang-Jeong, Yang, Sei-Hoon, Kwak, Tae Hwan, Lee, Chul-Ho, Park, Raekil, So, Hong-Seob
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2014
נושאים:
Basic Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944666/
https://ncbi.nlm.nih.gov/pubmed/24025646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.330
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