Pharmacological activation of NQO1 increases NAD(+) levels and attenuates cisplatin-mediated acute kidney injury in mice

Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors. In addition to its antitumor activity, cisplatin affects normal cells and may induce adverse effects, such as ototoxicity, nephrotoxicity, and neuropathy. Various mechanisms, such as DNA adduct formation, mitochon...

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Detalhes bibliográficos
Main Authors: Oh, Gi-Su, Kim, Hyung-Jin, Choi, Jae-Hyuck, Shen, AiHua, Choe, Seong-Kyu, Karna, Anzani, Lee, Seung Hoon, Jo, Hyang-Jeong, Yang, Sei-Hoon, Kwak, Tae Hwan, Lee, Chul-Ho, Park, Raekil, So, Hong-Seob
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944666/
https://ncbi.nlm.nih.gov/pubmed/24025646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.330
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