The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival

GPR109A, a G-protein-coupled receptor, is activated by niacin and butyrate. Upon activation in colonocytes, GPR109A potentiates anti-inflammatory pathways, induces apoptosis, and protects against inflammation-induced colon cancer. In contrast, GPR109A activation in keratinocytes induces flushing by...

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Detalhes bibliográficos
Main Authors: Elangovan, Selvakumar, Pathania, Rajneesh, Ramachandran, Sabarish, Ananth, Sudha, Padia, Ravi N., Lan, Ling, Singh, Nagendra, Martin, Pamela M., Hawthorn, Lesleyann, Prasad, Puttur D., Ganapathy, Vadivel, Thangaraju, Muthusamy
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944627/
https://ncbi.nlm.nih.gov/pubmed/24371223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1451
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