Two mutations in the HMG-box with very different structural consequences provide insights into the nature of binding to four-way junction DNA.

Mutation of the highly conserved tryptophan residue in the A-domain HMG-box of HMG1 largely, but not completely, destroys the protein tertiary structure and abolishes its supercoiling ability, but does not abolish structure-specific DNA binding to four-way junctions. Circular dichroism shows that th...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Teo, S H, Grasser, K D, Hardman, C H, Broadhurst, R W, Laue, E D, Thomas, J O
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC394459/
https://ncbi.nlm.nih.gov/pubmed/7641702
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky