Two mutations in the HMG-box with very different structural consequences provide insights into the nature of binding to four-way junction DNA.

Mutation of the highly conserved tryptophan residue in the A-domain HMG-box of HMG1 largely, but not completely, destroys the protein tertiary structure and abolishes its supercoiling ability, but does not abolish structure-specific DNA binding to four-way junctions. Circular dichroism shows that th...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Teo, S H, Grasser, K D, Hardman, C H, Broadhurst, R W, Laue, E D, Thomas, J O
פורמט: Artigo
שפה:Inglês
יצא לאור: 1995
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC394459/
https://ncbi.nlm.nih.gov/pubmed/7641702
תגים: הוספת תג
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