Two mutations in the HMG-box with very different structural consequences provide insights into the nature of binding to four-way junction DNA.

Mutation of the highly conserved tryptophan residue in the A-domain HMG-box of HMG1 largely, but not completely, destroys the protein tertiary structure and abolishes its supercoiling ability, but does not abolish structure-specific DNA binding to four-way junctions. Circular dichroism shows that th...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Teo, S H, Grasser, K D, Hardman, C H, Broadhurst, R W, Laue, E D, Thomas, J O
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1995
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394459/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7641702/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00054.x
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