Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

The interferon induced double-stranded RNA-activated kinase, PKR, has been suggested to act as a tumor suppressor since expression of a dominant negative mutant of PKR causes malignant transformation. However, the mechanism of transformation has not been elucidated. PKR phosphorylates translation in...

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Bibliografske podrobnosti
Main Authors: Donzé, O, Jagus, R, Koromilas, A E, Hershey, J W, Sonenberg, N
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC394457/
https://ncbi.nlm.nih.gov/pubmed/7641700
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