IgA EGFR antibodies mediate tumour killing in vivo

Currently all approved anti-cancer therapeutic monoclonal antibodies (mAbs) are of the IgG isotype, which rely on Fcgamma receptors (FcγRs) to recruit cellular effector functions. In vitro studies showed that targeting of FcαRI (CD89) by bispecific antibodies (bsAbs) or recombinant IgA resulted in m...

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Bibliografski detalji
Glavni autori: Boross, Peter, Lohse, Stefan, Nederend, Maaike, Jansen, Johannes Hendrik Marco, van Tetering, Geert, Dechant, Michael, Peipp, Matthias, Royle, Louise, Liew, Li Phing, Boon, Louis, van Rooijen, Nico, Bleeker, Wim K, Parren, Paul W H I, van de Winkel, Jan G J, Valerius, Thomas, Leusen, Jeanette H W
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2013
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944462/
https://ncbi.nlm.nih.gov/pubmed/23918228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201929
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