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IgA EGFR antibodies mediate tumour killing in vivo
Currently all approved anti-cancer therapeutic monoclonal antibodies (mAbs) are of the IgG isotype, which rely on Fcgamma receptors (FcγRs) to recruit cellular effector functions. In vitro studies showed that targeting of FcαRI (CD89) by bispecific antibodies (bsAbs) or recombinant IgA resulted in m...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Blackwell Science Inc
2013
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Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3944462/ https://ncbi.nlm.nih.gov/pubmed/23918228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201929 |
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