MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron–sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells

The cellular energy metabolism shift, characterized by the inhibition of oxidative phosphorylation (OXPHOS) and enhancement of glycolysis, is involved in nickel-induced neurotoxicity. MicroRNA-210 (miR-210) is regulated by hypoxia-inducible transcription factor-1α (HIF-1α) under hypoxic conditions a...

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Detalhes bibliográficos
Main Authors: He, M, Lu, Y, Xu, S, Mao, L, Zhang, L, Duan, W, Liu, C, Pi, H, Zhang, Y, Zhong, M, Yu, Z, Zhou, Z
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944272/
https://ncbi.nlm.nih.gov/pubmed/24577088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.60
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