MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

BACKGROUND: Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis. METHODS AND FINDINGS: In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur...

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Hauptverfasser: Favaro, Elena, Ramachandran, Anassuya, McCormick, Robert, Gee, Harriet, Blancher, Christine, Crosby, Meredith, Devlin, Cecilia, Blick, Christopher, Buffa, Francesca, Li, Ji-Liang, Vojnovic, Borivoj, Pires das Neves, Ricardo, Glazer, Peter, Iborra, Francisco, Ivan, Mircea, Ragoussis, Jiannis, Harris, Adrian L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859946/
https://ncbi.nlm.nih.gov/pubmed/20436681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010345
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