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The Human Iron–Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 That Can Be Transferred to Acceptor Molecules

Iron–sulfur (Fe–S) clusters are essential protein cofactors for most life forms. In human mitochondria, the core Fe–S biosynthetic enzymatic complex (called SDUF) consists of NFS1, ISD11, ISCU2, and frataxin (FXN) protein components. Few mechanistic details about how this complex synthesizes Fe–S cl...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Fox, Nicholas G., Chakrabarti, Mrinmoy, McCormick, Sean P., Lindahl, Paul A., Barondeau, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675461/
https://ncbi.nlm.nih.gov/pubmed/26016389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5014485
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