Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named ‘trained immunity’....

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Bibliographische Detailangaben
Hauptverfasser: Kleinnijenhuis, Johanneke, Quintin, Jessica, Preijers, Frank, Benn, Christine Stabell, Joosten, Leo A.B., Jacobs, Cor, van Loenhout, Joke, Xavier, Ramnik J., Aaby, Peter, van der Meer, Jos W.M., van Crevel, Reinout, Netea, Mihai G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: S. Karger AG 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944069/
https://ncbi.nlm.nih.gov/pubmed/24192057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000355628
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