Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Adaptive features of innate immunity, recently described as “trained immunity,” have been documented in plants, invertebrate animals, and mice, but not yet in humans. Here we show that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led not only to a four- to sevenfold increase in th...

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Bibliographic Details
Main Authors: Kleinnijenhuis, Johanneke, Quintin, Jessica, Preijers, Frank, Joosten, Leo A. B., Ifrim, Daniela C., Saeed, Sadia, Jacobs, Cor, van Loenhout, Joke, de Jong, Dirk, Stunnenberg, Hendrik G., Xavier, Ramnik J., van der Meer, Jos W. M., van Crevel, Reinout, Netea, Mihai G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491454/
https://ncbi.nlm.nih.gov/pubmed/22988082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202870109
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