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Preparation of new alkyne-modified ansamitocins by mutasynthesis
The preparation of alkyne-modified ansamitocins by mutasynthetic supplementation of Actinosynnema pretiosum mutants with alkyne-substituted aminobenzoic acids is described. This modification paved the way to introduce a thiol linker by Huisgen-type cycloaddition which can principally be utilized to...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Beilstein-Institut
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3943755/ https://ncbi.nlm.nih.gov/pubmed/24605171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.10.49 |
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