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Preparation of new alkyne-modified ansamitocins by mutasynthesis

The preparation of alkyne-modified ansamitocins by mutasynthetic supplementation of Actinosynnema pretiosum mutants with alkyne-substituted aminobenzoic acids is described. This modification paved the way to introduce a thiol linker by Huisgen-type cycloaddition which can principally be utilized to...

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Detalhes bibliográficos
Main Authors: Harmrolfs, Kirsten, Mancuso, Lena, Drung, Binia, Sasse, Florenz, Kirschning, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943755/
https://ncbi.nlm.nih.gov/pubmed/24605171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.10.49
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