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Broad substrate specificity of the amide synthase in S. hygroscopicus – new 20-membered macrolactones derived from geldanamycin
The amide synthase of the geldanamycin producer, Streptomyces hygroscopicus, shows a broader chemoselectivity than the corresponding amide synthase present in Actinnosynnema pretiosum, the producer of the highly cytotoxic ansamycin antibiotics, the ansamitocins. This was demonstrated when blocked mu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3292439/ https://ncbi.nlm.nih.gov/pubmed/22136518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2087147 |
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