Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis

BACKGROUND: The Mechanistic Target of Rapamycin (mTOR) pathway is a major regulator of cell immunity and metabolism. mTOR is a well-known suppressor of tissue rejection in organ transplants, however, it has other non-immune functions including in the cardiovascular system, where it is a regulator of...

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Hlavní autoři: Lassaletta, Antonio D, Elmadhun, Nassrene Y, Zanetti, Arthus V D, Feng, Jun, Anduaga, Javier, Gohh, Reginald Y., Sellke, Frank W, Bianchi, Cesario
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943541/
https://ncbi.nlm.nih.gov/pubmed/24266948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2013.09.059
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