Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array

BACKGROUND: The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of genomic fragments to probes on the chip. However, certain genomic factors may compromise the ability to measure methylation using...

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Hauptverfasser: Naeem, Haroon, Wong, Nicholas C, Chatterton, Zac, Hong, Matthew K H, Pedersen, John S, Corcoran, Niall M, Hovens, Christopher M, Macintyre, Geoff
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Methodology Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943510/
https://ncbi.nlm.nih.gov/pubmed/24447442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-51
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