Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array

BACKGROUND: The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of genomic fragments to probes on the chip. However, certain genomic factors may compromise the ability to measure methylation using...

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Detalhes bibliográficos
Main Authors: Naeem, Haroon, Wong, Nicholas C, Chatterton, Zac, Hong, Matthew K H, Pedersen, John S, Corcoran, Niall M, Hovens, Christopher M, Macintyre, Geoff
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943510/
https://ncbi.nlm.nih.gov/pubmed/24447442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-51
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