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JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

Targeted gene disruption studies have established that the c-Jun NH(2)-terminal kinase (JNK) is required for the stress-induced release of mitochondrial cytochrome c and apoptosis, and that the Bax subfamily of Bcl-2-related proteins is essential for JNK-dependent apoptosis. However, the mechanism b...

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Bibliografiske detaljer
Udgivet i:EMBO J
Principais autores: Tsuruta, Fuminori, Sunayama, Jun, Mori, Yasunori, Hattori, Seisuke, Shimizu, Shigeomi, Tsujimoto, Yoshihide, Yoshioka, Katsuji, Masuyama, Norihisa, Gotoh, Yukiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394248/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15071501/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600194
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