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Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models

Bioenergetic abnormalities and metabolic dysfunction occur in amyotrophic lateral sclerosis (ALS) patients and genetic mouse models. However, whether metabolic dysfunction occurs early in ALS pathophysiology linked to different ALS genes remains unclear. Here, we investigated AMP-activated protein k...

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Main Authors: Perera, Nirma D., Sheean, Rebecca K., Scott, John W., Kemp, Bruce E., Horne, Malcolm K., Turner, Bradley J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942426/
https://ncbi.nlm.nih.gov/pubmed/24595038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090449
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