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Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models

Bioenergetic abnormalities and metabolic dysfunction occur in amyotrophic lateral sclerosis (ALS) patients and genetic mouse models. However, whether metabolic dysfunction occurs early in ALS pathophysiology linked to different ALS genes remains unclear. Here, we investigated AMP-activated protein k...

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Autors principals: Perera, Nirma D., Sheean, Rebecca K., Scott, John W., Kemp, Bruce E., Horne, Malcolm K., Turner, Bradley J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942426/
https://ncbi.nlm.nih.gov/pubmed/24595038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090449
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