Therapeutic Polyclonal human CD8+ Fox3+ TNFR2+ PD-L1+ Regulatory Cells Induced ex-vivo

We report that polyclonal CD8regs generated in one week ex-vivo with anti-CD3/28 beads and cytokines rapidly developed suppressive activity in vitro sustained by TGF-β. In immunodeficient mice, these CD8regs demonstrated a markedly protective, IL-10 dependent activity against a xeno-GVHD. They expre...

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Detalhes bibliográficos
Main Authors: Horwitz, David A., Pan, Stephanie, Ou, Jing-Ni, Wang, Julie, Chen, Maogen, Gray, J. Dixon, Zheng, Song Guo
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941976/
https://ncbi.nlm.nih.gov/pubmed/24211847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2013.08.007
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