Effects of I(Kur) blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation

Selective blockers of the Kv1.5 channel have been developed for the treatment of atrial fibrillation (AF), but little is known how these atrial-selective drugs affect human action potentials (APs). Therefore we have investigated the Kv1.5 blocker MK-0448 (N-{6-[(1S)-1-(4-fluorophenyl)-2,2-di(pyridin...

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Bibliographic Details
Main Authors: Loose, Simone, Mueller, Judith, Wettwer, Erich, Knaut, Michael, Ford, John, Milnes, James, Ravens, Ursula
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940943/
https://ncbi.nlm.nih.gov/pubmed/24624083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00026
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