The positive frequency-dependent electrophysiological effects of the I(Kur) inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation

BACKGROUND: Selective inhibitors of K(v)1.5 channels are being developed for the treatment of atrial fibrillation (AF). OBJECTIVES: The purpose of this study was to investigate the effects of the highly selective K(v)1.5 inhibitor XEN-D0103 on human atrial action potentials (APs) at high excitation...

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Detalhes bibliográficos
Publicado no:Heart Rhythm
Main Authors: Ford, John, Milnes, James, El Haou, Said, Wettwer, Erich, Loose, Simone, Matschke, Klaus, Tyl, Benoit, Round, Patrick, Ravens, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768384/
https://ncbi.nlm.nih.gov/pubmed/26455450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2015.10.003
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