Effects of I(Kur) blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation

Selective blockers of the Kv1.5 channel have been developed for the treatment of atrial fibrillation (AF), but little is known how these atrial-selective drugs affect human action potentials (APs). Therefore we have investigated the Kv1.5 blocker MK-0448 (N-{6-[(1S)-1-(4-fluorophenyl)-2,2-di(pyridin...

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Detalhes bibliográficos
Principais autores: Loose, Simone, Mueller, Judith, Wettwer, Erich, Knaut, Michael, Ford, John, Milnes, James, Ravens, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940943/
https://ncbi.nlm.nih.gov/pubmed/24624083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00026
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