The Synthetic α-Bromo-2′,3,4,4′-Tetramethoxychalcone (α-Br-TMC) Inhibits the JAK/STAT Signaling Pathway

Signal transducer and activator of transcription STAT5 and its upstream activating kinase JAK2 are essential mediators of cytokine signaling. Their activity is normally tightly regulated and transient. However, constitutive activation of STAT5 is found in numerous cancers and a driving force for mal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pinz, Sophia, Unser, Samy, Brueggemann, Susanne, Besl, Elisabeth, Al-Rifai, Nafisah, Petkes, Hermina, Amslinger, Sabine, Rascle, Anne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940872/
https://ncbi.nlm.nih.gov/pubmed/24595334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090275
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